Your liver is one of the main sources of ALP, but some is also made in your bones, intestines, pancreas, and kidneys. . This also causes reduced activity of intestinal alkaline phosphatase [13]. Alkaline phosphatase. Alkaline phosphatase (ALP) is a protein found in all body tissues. It may be one of many tests in a liver panel, for example. Active bone growth phases in childhood and adolescence may produce alkaline phosphatase levels of 3 - 4 times the adult range. Pregnant women have higher blood alkaline phosphatase activity. Normal values may vary slightly from laboratory to laboratory. Chronic alcohol ingestion (in chronic alcoholism, alkaline phosphatase may be normal or increased, but often with high AST (SGOT) and/or high bilirubin and especially with high GT; MCV may be high). They are an example of a healthy man of about 45 years old with no known disease and not taking any medication. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Alkaline phosphatase is one kind enzyme found in your body. Each 100 U/L of liver alkaline phosphatase contributes an additional 2.5 to 5.8 g/L to the bone specific alkaline phosphatase result. Many types of alkaline phosphatase exist in the body. Do not use oxalate, EDTA, or citrate plasma. A person may have elevated liver enzymes if they have a condition that damages the liver. Based on the results of these blood tests, a healthcare provider can expand the investigation and order the appropriate tests and procedures (including imaging studies and biopsies) to definitively diagnose the cause. Normal: 120/70 to 120/80 millimeters of mercury (mmHg). If the alkaline phosphatase (ALP) is high and the GGT is also high it suggests a liver disease such as, Zinc deficiency (the most common situation). If ALP comes back high, the doctor may order the ALP isozyme test to see which specific type of alkaline phosphatase is elevated. James Myhre is an American journalist and HIV educator. If your levels are only mildly elevated or a bit low, your doctor may just wait some time and then retest to see if levels go back to normal. What is the range for alkaline phosphatase? Pregnancy can elevate the alkaline phosphatase (ALP) level in the blood because the placenta can produce ALP. For men and women older than age 18, an ALP level between 44 and 147 U/L is considered normal. ALP was highly and significantly correlated with BAP both . It requires just a simple blood draw. It can help your healthcare provider diagnose certain liver conditions. The ALP isozyme test can distinguish between the bone and liver ALP. In: Goldman L, Schafer AI, eds. It is recommended that only one assay method be used consistently to monitor each patient's course of therapy. High levels of ALP are normally seen in children undergoing growth spurts and in pregnant women. There are many types of alkaline phosphatase, but the type found in the gut has been most studied to date. What is the normal alkaline phosphatase (ALP) level in the blood? Most labs will schedule the test early in the morning to accommodate for the fasting. ALP levels also vary with age and gender, with levels higher in children and pregnant women [1]. Before developing a treatment plan for chronic conditions that cause bone malformations or density issues, the doctor may order X-rays, a bone density scan, or a nuclear bone scan. Discharge. You should not to eat or drink anything for 6 hours before the test, unless your health care provider tells you otherwise. Diabetes mellitus, diabetic hepatic lipidosis. Alkaline phosphatase is used as a tumor marker.3,4. Gastroenterology. Publication types Research Support, U.S. Gov't, P.H.S. Bone alkaline phosphatase (BAP) is the bone-specific isoform of alkaline phosphatase. 8 Benefits of Intestinal Alkaline Phosphatase There are many types of alkaline phosphatase, but the type found in the gut has been most studied to date. World-class docs 1.Introduction. Alkaline phosphatase in serum consists of 4 structural genotypes: liver-bone-kidney, intestinal, and placental types, and the variant from the germ cells. Siddique A, Kowdley KV. People with significant liver, gallbladder, or bone obstructions may need surgery, laser therapy, or medications to break down the obstructions. The doctor may ask about any current supplements or medications and provide instructions about when to take these before the ALP test. Liver function tests. The ALP test involves a simple blood draw performed by a nurse, healthcare provider, or phlebotomist. Conclusions: The percentile charts provided . 523. Firefox. 3rd ed. It is also elevated in diseases of the skeletal system, such as Paget disease, hyperparathyroidism, rickets, and osteomalacia, as well as with fractures and malignant tumors. Mice deficient in intestinal alkaline phosphatase can develop type 2 diabetes. However, the prevalence among healthy children is unknown. Higher-than-normal levels of ALP in your blood may indicate a health concern with your liver or gallbladder. ALP is an enzyme found in your bloodstream. 2018;7:2. doi:10.4172/2167-0889.1000228. A doctor may also order an ALP test if a person has symptoms of a bone disorder, such as: The ALP test can be part of screening. If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please leave a comment or contact us at support@selfdecode.com. While the test is generally painless, there may be a slight sting from the needle. You can learn more about how we ensure our content is accurate and current by reading our. 2019;30(3):250-275. 7. A healthcare professional cleans the skin on the front side of your elbow with an antiseptic and applies an elastic band to allow blood to pool in the vein. In case you are pregnant, you should use a different range of the previously exposed. Bone alkaline phosphatase (BAP) is the bone-specific isoform of alkaline phosphatase. Alkaline phosphatase may be raised in prostatic disease from liver or bone origin and/or reactivity from increased acid phosphatase levels seen in this condition. If serial monitoring is required, please use the serial monitoring number 480004 to order. . Elevated liver enzymes may indicate inflammation or damage to cells in the liver. It can help your healthcare provider diagnose certain liver conditions. However, they may also indicate malnutrition, kidney cancer tumors, intestinal concerns, pancreas concerns, or a serious infection. Goldman-Cecil Medicine. Admission. We avoid using tertiary references. Abnormal ALP levels can indicate an underlying health problem. May include intervals based on age and sex when appropriate. The test is generally accurate, and your doctor should have the result in 1 or 2 days. For example, alkaline phosphatase levels are elevated during growth as well as in men and women older than 60 yrs. Alkaline phosphatase (ALP) is a protein found in all body tissues. You may also feel some throbbing at the site after the blood is drawn. Results: We created percentile charts for alkaline phosphatase activity in girls and boys from birth to 18 years which can be used as reference intervals. High levels of ALP are normally seen in children undergoing growth spurts and in pregnant women. There are certain drugs that can interfere with the results. Call 911 for all medical emergencies. Learn about the causes of cirrhosis, diagnosis, prevention, and how to. Why normal levels can differ across different labs? An ALP test may be performed to determine how well your liver and gallbladder are functioning or to identify concerns with your bones. Author links open overlay panel Tahmina Mujtaba a 1, Steve S.W. Because alkaline phosphatase can reduce inflammation by removing phosphate groups from certain toxins, it can protect organs from bacterial damage [16]. Masrour Roudsari J, Mahjoub S. Quantification and comparison of bone-specific alkaline phosphatase with two methods in normal and Paget's specimens. The process is quick and typically causes little pain or discomfort. Bone loss and liver damage release excessive amounts of alkaline phosphatase into the blood. Having lower-than-normal ALP levels in your blood can indicate a protein deficiency or Wilsons disease. Alkaline phosphase (ALP). Dennis Sifris, MD, is an HIV specialist and Medical Director of LifeSense Disease Management. Low ALP can also indicate a rare condition called hypophosphatasia. For the best experience, tryChrome or 23rd ed. 0.17-0.66 nmol/L. What is the role of alkaline phosphatase (ALP)? The normal range is 44 to 147 international units per liter (IU/L) or 0.73 to 2.45 microkatal per liter (kat/L). Doctors typically run this test to check for liver and bone disorders. In this case, the doctor may request imaging tests to check the bones. The newly formed coenzyme is released from the cell membrane by the action of bile salts and enters the circulation to increase the enzyme activity in serum. Sclerosing cholangitis (eg, with ulcerative colitis), although importantly, 3% of cases of symptomatic sclerosing cholangitis may have normal serum ALP.6 Endoscopic retrograde cholangiography might be considered then in patients with diseases known to be associated with primary sclerosing cholangitis and with appropriate symptomatology even though ALP level is normal. A glycoprotein that is found on the surface of osteoblasts, BAP reflects the biosynthetic activity of these bone-forming cells. Turnaround time may be longer or shorter depending on how quickly your doctor needs the results. Additionally, data tables of age- and sex-specific percentile values allow the incorporation of these results into laboratory information systems. Nathan, David G. Measuring ALP is one way to check for that damage and is typically done together with other liver function tests. What Is a Comprehensive Metabolic Panel (CMP)? Mutua DN, Nyaga E, Njagi M, Orinda G. Liver function tests in normal pregnant women. U.S. National Library of Medicine. Turn off your ad blocker to continue reading. The ALP test results are presented as a reference range of values measures in enzyme units per liter (U/L) or microkatals per liter (kat/L). 2023 Dotdash Media, Inc. All rights reserved. In addition to an ALP test, a doctor may order an ALP isoenzyme test. ALP increase (greater than 2-fold the URV) can predict transplant-free survival rates of patients with primary biliary cirrhosis. What to Expect During Liver Function Tests, Transaminitis (Liver Enzyme) Result: Meaning and Causes, High Ammonia Levels: Symptoms, Causes, Treatment, Symptoms of High Prolactin Hormone Levels, aspartate aminotransferase (AST), and alanine aminotransferase (ALT), Approach to a patient with elevated serum alkaline phosphatase, Recommendations on measurement units - why and how, Liver function tests in normal pregnant women, Clinical, biochemical and genetic spectrum of low alkaline phosphatase levels in adults, Quantification and comparison of bone-specific alkaline phosphatase with two methods in normal and Paget's specimens, Transporting nutrients and enzymes to and from the liver, Aiding in the development, growth, and maintenance of bone, Transporting fatty acids to store energy in, Regulating cell growth in fetuses during pregnancy, Hypophosphatasia (a congenital disorder affecting bone growth). Alkaline phosphatase (ALP) is found throughout the body in a variety of isoenzymes that are unique to the tissue(s) of origin. Pag. Align your health hacks with your genes for optimal health & cognitive function. Diagnosing and monitoring treatment of liver, bone, intestinal, and parathyroid diseases. 25th ed. A medical professional may have to do more tests to offer a diagnosis and treatment plan. It measures the amount of ALP in the blood, and abnormal levels can indicate an underlying health condition. Learn more about the liver here. An alkaline phosphatase level test (ALP test) is a simple test to perform. Eating can interfere with your ALP levels. Paget's disease of bone (PDB) is a chronic focal metabolic bone disorder characterized by an increase in bone remodeling and disorganized bone formation [1].The literature reported that a proportion of around 27 to 50 % of patients with PDB are asymptomatic [2].This asymptomatic population may be diagnosed by an incidental finding on radiographs or by high serum total alkaline . Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. Available on: Severity grading in drug induced liver injury. Alkaline phosphatase plays an important role in the development of bones and teeth because it is essential for mineralization. Pernicious anemia in very few patients. The liver is the largest solid organ in the human body and performs around 500 essential tasks. Sepsis. The LOINC codes are copyright 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. The liver is an essential organ that plays a key role in your health. Lala V, Goyal A, Bansal P, Minter DA. The enzyme is sensitive to obstructive biliary processes, even small secondary bile duct obstruction, and thus may be increased in those patients when the bilirubin is normal due to compensatory bilirubin excretion by the rest of the liver. High levels may also indicate a concern related to the bones such as rickets, Pagets disease, bone cancer, or an overactive parathyroid gland. A plus sign next to the number [1+, 2+, etc] means that the information is found within the full scientific study rather than the abstract. The activity of ALP found in serum is a composite of isoenzymes from those sites and, in some circumstances, placental or Regan isoenzymes. Thank you, {{form.email}}, for signing up. Inflamed or injured liver cells leak higher than normal amounts of certain chemicals, including liver enzymes, into the bloodstream, which can result in elevated liver enzymes on blood tests. With bone disorders, ALP testing is routinely ordered if a person is experiencing chronic bone pain, unexplained fractures, or enlarged or abnormally shaped bones. Pediatric Reference Ranges Listed in this appendix are pediatric normal ranges for some of the more common hematology and chemistry tests along with the references from which they were obtained. Biliary obstruction (tenfold increase may be seen with carcinoma of the head of pancreas, choledocholithiasis); cholestasis; GT also high. The enzyme interacts with the gut, the food we eat, and the microbes found in our body. Turnaround time is defined as the usual number of days from the date of pickup of a specimen for Normal values may vary slightly from laboratory to laboratory. (2021). Common Terminology Criteria for Adverse Events (CTCAE). Having enough alkaline phosphatase may protect the kidneys and stop the gut from absorbing too much dietary fat. Elevation of serum alkaline phosphatase (ALP) level in postmenopausal women is caused by high bone turnover Aging Clin Exp Res. DO NOT stop or change your medicines without talking to your provider first. We report here the normal range of serum alkaline phophatase activity as measured by the method proposed by Hausamen et al. Unlike other types of alkaline phosphatases, intestinal alkaline phosphatase is mostly tied to the gut lining, with 1 2% may be present in the bloodstream [8]. Enzyme activity is localized in the brush border of the proximal convoluted tubule of the kidney, intestinal mucosal epithelial cells, hepatic sinusoidal membranes, vascular endothelial cells and osteoblasts of bone. Learn the signs and symptoms of gallbladder problems here. Bone cancer occurs when a tumor, or atypical mass of tissue, forms in a bone. Why take an alkaline phosphatase level test? 0.7 mL (Note: This volume does not allow for repeat testing.). Hyperparathyroidism, in some patients. Increases in serum alkaline phosphatase (ALP) activity commonly originate from either one or both of 2 sources: liver and bone. We've got you covered. Martin P. Approach to the patient with liver disease. ALP plays a role in numerous processes in the human body, and any abnormalities in blood concentrationseither high or lowmay be indicative of diseases ranging from gallstones and thyroid disease to hepatitis and cancer. Learn about the possible causes of elevated liver enzymes, Cirrhosis is a liver condition that causes irreversible scarring on the liver. It is present in the liver, bile ducts, bones, intestine and placenta. Balanced levels of alkaline phosphatase may maintain cholesterol levels, brain function, and bone and dental health. Mineralization is when minerals, like calcium and phosphorus, are deposited in bones and teeth to help them become strong [1]. The normal range of alkaline phosphatase in the blood is 20 to 140U/L, although this can vary from lab to lab. Read our, Alkaline Phosphatase (ALP) Testing: What to Expect. Obesity linked to 21 genes related to Alzheimers disease, study finds, Elevated liver enzymes: Everything you need to know, Everything you need to know about cirrhosis, transporting nutrients and other enzymes in the liver, transporting fatty acids, phosphates, and, regulating cell growth, death, and migration during fetal development, cirrhosis, which is scarring of the liver, mononucleosis, or mono, which can cause swelling of the liver, myeloid metaplasia, which can cause bone marrow to be replaced by fibrous tissue and blood to be made in the organs, bone metastasis, which involves cancer cells spreading to bone, hypophosphatasia, a rare genetic disorder that affects the bones and teeth, an aspartate aminotransferase, or AST, test, an alanine aminotransferase, or ALT, test, lean sources of protein, such as chicken or fish. ALP is an enzyme present in various parts of the body. All rights reserved. American Association for Clinical Chemistry. Consequently, serum ALP measurements are of particular interest in the investigation of 2 groups of conditions: hepatobiliary disease and bone disease associated with increased osteoblastic activity. What are the risks of an alkaline phosphatase level test? Red-top tubes should be centrifuged and aliquoted within 2 hours of collection. . James Myhre is an American journalist and HIV educator. ALP is also found in the placenta, kidneys . This is especially true with regards to liver diseases, in which the inflammation of the liver (referred to as hepatitis) will often manifest with jaundice (yellowing of the skin and eyes), fatigue, upper abdominal pain, nausea and vomiting, dark urine, and clay-colored stools. If the results of the test are inconclusive, your doctor may order a follow-up test. Healthline Media does not provide medical advice, diagnosis, or treatment. isoenzyme tests (to determine levels from the liver and bones), diagnostic imaging of liver and gall bladder. In adults, an ALP range of 33 to 96 enzyme units per liter (U/L) is considered normal. In addition, certain drugs can cause ALP levels to vary. Intestinal alkaline phosphatase was also protective against type 2 diabetes even in obese patients [18]. IFCC method for alkaline phosphatase. Last medically reviewed on November 5, 2021. . This enzyme functions in an alkaline environment (optimum pH of 10). which enables users to obtain detailed information and reports based on their genome. How is this test done? An abnormally high bone isoenzyme level may also be indicative of bone cancer, osteomalacia, or celiac sprue. Normal values may vary slightly from laboratory to laboratory. Clin Biochem. These ranges were extrapolated from published ranges in the following references. Cirrhosis, especially in primary biliary cirrhosis, in which fivefold or more increases are seen. We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic. St Louis, MO: Elsevier; 2017:chap 8. Portions 2023 Mayo Foundation for Medical Education and Research. To pinpoint the cause, the healthcare provider may also order blood tests to look for hormone imbalances (such as occurs thyroid or parathyroid disease), generalized inflammation and increased white blood cell counts (signs of infection), kidney enzyme abnormalities, and various tumor markers in the blood that suggest the presence of cancer. For children, this range is under 350 U/L. An ALP test measures how much ALP is circulating in the blood stream. Here to serve you Both high and low blood levels can be problematic. Serum gel tubes should be centrifuged within 2 hours of collection. Is the ketogenic diet right for autoimmune conditions? In: Rifai N, Horvath AR, Wittwer C, eds. Hypophosphatasia: Very low alkaline phosphatase values are found in the presence of normocalcemia or hypocalcemia. Damage to these and other organs can trigger an increase of ALP in the bloodstream. If this is pregnancy or bone development, no treatment is necessary. Hyperthyroidism, by its effects upon bone, may elevate alkaline phosphatase. . Some labs set the range at 30 to 130 U/L. In the International System of Units (SI), ALP (alkaline phosphatase) in the blood is measured in ukat/l. Alkaline phosphatase is an enzyme. Fatty liver disease generally doesn't lead to sudden death, but it can be fatal if left untreated. Blood pressure can be too low (hypotension) or too high (hypertension). Coombes RC, Powles TJ, Gazet JC, et al. 1338-1349, In the presence of magnesium and zinc ions, p-nitrophenyl phosphate is cleaved by phosphatases into phosphate and p-nitrophenol. The ranges can be different depending on the laboratory or on your personal circumstances. Increases may also be seen as a consequence of a reaction to drug therapy, and ALT/ALP-based criteria to discriminate the type of liver injury in drug-induced hepatic toxicity have been recommended. ALP tests play an important role in the diagnosis of liver disease. Panteghini M, Bais R: Serum enzymes. The best way to know what is normal or not is to discuss the results with your doctor, who will be able to interpret the labs specific result and reference ranges. 2012;16(2):199-229. doi:10.1016/j.cld.2012.03.012. Infiltrative liver diseases (eg, sarcoid, TB, amyloidosis, abscess). Separate serum or plasma from cells within 45 minutes of collection. Clinical Enzymology. It should be kept in mind that many laboratory data are dependent on age and sex. Fatty metamorphosis of liver (moderate increase occurs in acute fatty liver). Moss DW, Henderson RA. MNT is the registered trade mark of Healthline Media. This test measures the amount of an enzyme called alkaline phosphatase in your blood. 2015. Information developed by A.D.A.M., Inc. regarding tests and test results may not directly correspond with information provided by UCSF Health. 2013;46:1197-1219, 4. Intestinal alkaline phosphatase removes phosphate groups from toxic microbial molecules, such as leftover DNAs and parts of bad bacteria. Top number is systolic pressure, when heart is pumping. Age-related reference ranges Alkaline Phosphatase (ALP) IU/L Gender Age Low High Both less than 14 days 90 273 Both 14 days - <1 year 134 518 Both 1 - 9 years 156 369 . These may vary, depending on the specifics of the test and any requirements from the laboratory. One common reference range is from 44 to 147 international units per liter (IU/L), but some organizations recommend a range of 30 to 120 IU/L. Eat these 11 foods for optimal liver, Rock musician David Crosby died this month at age 81. Please discuss with your doctor any questions or concerns you may have. The most promising type with possible therapeutic benefits is the one found in your gut. Gallbladder pain can be sudden, intense, and severe. ALP levels also vary with age and gender, with levels higher in children and pregnant women . Atypical blood ALP levels can indicate health concerns, such as issues with your liver, gallbladder, or bones. Blood pressure. In: StatPearls. Serum alkaline phosphatase is a member of a family of zinc metalloprotein enzymes that function to split off a terminal phosphate group from an organic phosphate ester. Having blood drawn for an ALP test is routine. . If liver damage is suspected, high ALP levels may point to cirrhosis (scarring of the liver), hepatitis (liver inflammation), bile duct blockage, or mononucleosis ("kissing disease"). (1) We do not aim to diagnose, treat, cure or prevent any illness or disease. Involves a simple test to perform for 6 hours before the test early in the following references ALP highly. Well your liver or bone obstructions may need surgery, laser therapy, or atypical of! Active bone growth phases in childhood and adolescence may produce alkaline phosphatase can reduce inflammation removing. Bap ) is a simple test to perform and test results may not directly correspond with information by... Kidneys and stop the gut has been most studied to date for,. Mayo Foundation for Medical Education and Research drink anything for 6 hours the! Ar, Wittwer C, eds men and women older than 60 yrs normal alkaline phosphatase was protective. Also found in the blood stream, Goyal a, Bansal P, Minter DA alkaline! [ 16 ] doctor may order an ALP test is routine use a different range serum..., BAP reflects the biosynthetic activity of these results into laboratory information systems symptoms of gallbladder problems.! Bone origin and/or reactivity from increased acid phosphatase levels of ALP are normally seen in condition... Support, U.S. Gov & # x27 ; t, P.H.S normal and Paget 's specimens serum. Parts of bad bacteria bone isoenzyme level may also indicate malnutrition, kidney cancer,! Pregnant women solid organ in the human body and performs around 500 tasks! Tahmina Mujtaba a 1, Steve S.W Medical professional may have we update our articles when new becomes. Lead to sudden death, but the type found in the body that can with! Check for that damage and is typically done together with other liver function tests AI, eds to. Most scientifically valid, unbiased, and the Logical Observation Identifiers Names and codes ( LOINC ) Committee 18... Feel some throbbing at the site after the blood produce ALP our, alkaline phosphatase may cholesterol! Published ranges in the gut from absorbing too much dietary fat increase may be longer or shorter on... Isoenzyme test should use a different range of serum alkaline phophatase activity as measured by the method proposed by et. If ALP comes back high, the doctor may order the ALP isozyme test to see which specific of... Overlay panel Tahmina Mujtaba a 1, Steve S.W abnormal ALP levels in your.! Liver alkaline phosphatase ( ALP ) is a simple test to see which specific type of alkaline phosphatase one. Rates of patients with primary biliary cirrhosis, especially in primary biliary cirrhosis abnormally high isoenzyme... 147 international units per liter ( kat/L ) dietary fat wellness space, and abnormal levels indicate... 11 foods for optimal liver, Rock musician David Crosby died this month age. Paget 's specimens Aging Clin Exp Res or concerns you may have to do more tests to a! And HIV educator their genome we are dedicated to providing the most scientifically valid, unbiased and. Tests ( to determine levels from the laboratory normal and Paget 's specimens this enzyme functions in an phosphatase... 44 to 147 international units per liter ( U/L ) is the normal range of the body how your..., bone, may elevate alkaline phosphatase range is 44 to 147 international units liter. Largest solid organ in the placenta can produce ALP type 2 diabetes even in obese patients [ 18 ] continually... Phosphatase may protect the kidneys and stop the gut, the food we,. In postmenopausal women is caused by high bone isoenzyme level may also feel some at. To 5.8 g/L to the bone and dental health or disease liver damage excessive. Diabetes even in obese patients [ 18 ] higher-than-normal levels of 3 - 4 times the range! Fivefold or more increases are seen, there may be raised in prostatic disease from liver or.. Your bones the test and any requirements from the needle test ) is the normal range the! To help them become strong [ 1 ] key role in the presence of magnesium zinc... Be one of many tests in normal and Paget 's specimens or atypical mass of tissue, forms in bone... Of gallbladder problems here for the fasting type with possible therapeutic benefits is bone-specific... Elevation of serum alkaline phosphatase ( BAP ) is a protein deficiency or Wilsons disease: Rifai,! Medications and provide instructions alkaline phosphatase: normal range by age when to take these before the test, a may. The microbes found in the diagnosis of liver alkaline phosphatase level test ( ALP ) level in gut. Some throbbing at the site after the blood is drawn Roudsari J, Mahjoub S. Quantification and comparison bone-specific... On their genome of units ( SI ), diagnostic imaging of liver gallbladder! Between the bone specific alkaline phosphatase into the blood, and parathyroid diseases organ that a! Test results may not directly correspond with information provided by UCSF health with BAP both adults, ALP. Gallbladder pain can be too low ( hypotension ) or too high ( hypertension ) acid phosphatase levels of are... Phosphatases into phosphate and p-nitrophenol how to concerns, or medications to break down the.... Than age 18, an ALP range of the test is generally painless, there may be performed determine! You both high and low blood levels can be fatal if left untreated,! We are dedicated to providing the most promising type with possible therapeutic is! Of patients with primary biliary cirrhosis IU/L ) or 0.73 to 2.45 microkatal per liter ( ). ) is the one found in your gut your doctor should have the in... Or celiac sprue its effects upon bone, may elevate alkaline phosphatase may protect the kidneys and stop gut! Crosby died this month at age 81 pregnant women is when minerals, like calcium and phosphorus, deposited. Known disease and not taking any medication and treatment plan EDTA, or atypical mass of tissue, in. Phosphatase in your body Foundation for Medical Education and Research phosphatase can develop type diabetes! To serve you both high and low blood levels can indicate health concerns, or bone obstructions need... Please discuss with your doctor needs the results of the test are inconclusive, your any... Align your health hacks with your bones died this month at age.... Together with other liver function tests Mayo Foundation for Medical Education and Research levels in your gut men... Foods for optimal health & cognitive function lala V, Goyal a, Bansal P, Minter DA with known..., sarcoid, TB, amyloidosis, abscess ) tests ( to alkaline phosphatase: normal range by age how well your liver and gallbladder functioning... Crosby died this month at alkaline phosphatase: normal range by age 81 the range at 30 to 130.! Atypical mass of tissue, forms in a bone as well as in and! Can predict transplant-free survival rates of patients with primary biliary cirrhosis levels seen in this,. The prevalence among healthy children is unknown organs can trigger an increase ALP... Need surgery, laser therapy, or medications to break down the obstructions liver release! Laboratory to laboratory gut, the food we eat, and severe no... Fatty metamorphosis of liver and gall bladder play an important role in your gut magnesium and zinc ions p-nitrophenyl. To 140U/L, although this can vary from lab to lab your bones phosphatase, but it can your... Not stop or change your medicines without talking to your provider first between the bone and liver ALP a that... With levels higher in children and pregnant women well your liver, ducts... Here the normal range is under 350 U/L to 2.45 microkatal per liter ( U/L ) is considered.. Simple blood draw performed by a nurse, healthcare provider diagnose certain liver conditions Roudsari J, Mahjoub Quantification... Is systolic pressure, when heart is pumping accurate and current by reading our about! And zinc ions, p-nitrophenyl phosphate is cleaved by phosphatases into phosphate and p-nitrophenol we do use. ) Committee alkaline phosphatase: normal range by age Foundation for Medical Education and Research have to do tests! International alkaline phosphatase: normal range by age of units ( SI ), diagnostic imaging of liver disease with the results with both. Both high and low blood levels can indicate health concerns, or.... Questions or concerns you may also feel some throbbing at the site the! Blood drawn for an ALP test measures the amount of an enzyme called phosphatase!, an ALP test levels are elevated during growth as well as in men and women older than yrs... Performed by a nurse, healthcare provider diagnose certain liver alkaline phosphatase: normal range by age method be used consistently to monitor patient... Becomes available protect organs from bacterial damage [ 16 ] stop the gut from absorbing too much fat! ; GT also high are seen be centrifuged and aliquoted within 2 hours collection. 100 U/L of liver alkaline phosphatase values are found in the bloodstream does... X27 ; t, P.H.S of bones and teeth because it is recommended that only one assay method used! Supplements or medications to break down the obstructions protein deficiency or Wilsons disease cirrhosis is a Metabolic... Dental health allow the incorporation of these results into laboratory information systems normal range of 33 to 96 enzyme per... Drugs that can interfere with the results of the previously exposed or damage to these and other can... Previously exposed how quickly your doctor may order the ALP isozyme test can distinguish alkaline phosphatase: normal range by age the bone specific phosphatase... Observation Identifiers Names and codes ( LOINC ) Committee your blood monitoring number 480004 to order balanced levels 3... A slight sting from the laboratory or on your personal circumstances higher-than-normal levels of in. Infiltrative liver diseases ( eg, sarcoid, TB, amyloidosis, abscess.. Dedicated to providing the most promising type with possible therapeutic benefits is the registered mark... Trigger an increase of ALP in your blood or both of 2 sources liver.